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为研究口腔粘膜白斑及鳞癌组织中细胞凋亡及探讨粘膜白斑癌变有关机理 ,对 3 7例口腔粘膜白斑和 2 0例鳞癌石蜡切片用 TUNEL法检测了细胞凋亡情况 ,并计算其细胞凋亡率。结果表明 ,随着单纯增生性白斑、不典型增生性白斑和鳞癌形成 ,其细胞凋亡率呈明显下降趋势 ,三者间两两比较 ,差异均有显著性 (P<0 .0 1)
In order to study the mechanism of apoptosis in oral leukoplakia and squamous cell carcinoma and to explore the mechanism of leukoplakia, 37 cases of oral leukoplakia and 20 cases of squamous cell carcinoma paraffin sections were examined for apoptosis by TUNEL method and their cells Apoptosis rate. The results showed that with the formation of simple hyperplasia of leukoplakia, atypical hyperplasia and squamous cell carcinoma, the apoptotic rate showed a significant downward trend, with any significant difference between the three (P <0.01)