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黑质(SN)-纹状体多巴胺(DA)能神经元系统在调节躯体运动方面起着重要作用;但这一作用的传出神经通路尚无定论。在大鼠,丘脑腹内侧核(VM)是基底神经节的传出投射之一,主要接受SN网状部(SNR的投射纤维。本实验观察电损毁VM后,腹腔注射去水吗啡对大鼠姿势与行为的影响,以探讨SN-纹状体DA能神经元系统与VM在调节躯体运动中的功能联系。1 材料与方法 实验采用Sprague-Dawley系雄性大鼠,体重为200～300g,分为对照组(n=10)和实验组(n=11)。在1％成巴比妥钠麻醉下,将动物固定于立
The substantia nigra (SN), a striatal dopaminergic neuron system, plays an important role in the regulation of somatic motor movement; however, there is no conclusive evidence of this neural pathway. In the rat, the ventromedial thalamic nucleus (VM) is one of the outgoing projections of the basal ganglia and mainly receives the SN mesorectum (SNR of the projected fibers.) In this experiment, after VM was electrically destroyed, intraperitoneal injection of desmethylmorphine Posture and behavior of SN-striatal DA neurons to investigate the functional relationship between SN-striatal DA neurons and VM in regulating somatic motor function.Materials and MethodsSprague-Dawley male rats weighing 200-300 g The control group (n = 10) and the experimental group (n = 11) were anesthetized with 1% sodium pentobarbital