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目的对用凯时临床治疗急性脑梗死80例病例进行总结分析。方法80例急性脑梗塞患者,年龄52～72岁,平均(63.0±8.2)岁,随机分为治疗组(凯时注射液组)和对照组(复方丹参液组)各40例。所有患者均依据1995年第四届全国脑血管病学术会议标准,并经头颅MRI、CT检查证实为急性脑梗塞。治疗组给予凯时注射液,对照组予以复方丹参16 mL低分子右旋糖酐500 mL。所有观察对象治疗前停用其他抗血小板聚集抗凝及扩血管药物。两组疗程均为15 d,分别于治疗前及治疗15 d后测定血液流变学及甲襞微循环。结果治疗组治疗后血液流变学检查全血高切粘度、全血低切粘度和纤维蛋白原均显著下降,尤以全血低切黏度和纤维蛋白原最为明显,且明显低于对照组治疗后。对照组治疗后较治疗前各项指标稍有好转,但除全血高切黏度外其余各项指标经统计学处理差异无显著性。两组治疗前后甲襞微循环变化治疗组治疗后甲襞微循环,血流速度,流态等均显著改善,总积分值下降。对照组治疗后稍有好转。结论凯时注射液不仅在治疗急性脑梗塞方面有显著疗效,而且还通过改善血流变、微循环而能预防缺血性脑血管病的发生和发展,通过延长给药时间效果更佳,值得临床进一步推广和使用。
Objective To analyze the clinical treatment of 80 cases of acute cerebral infarction with Kay. Methods Eighty patients with acute cerebral infarction, aged from 52 to 72 years old, averaged (63.0 ± 8.2) years, were randomly divided into treatment group (Kai Shi injection group) and control group (Fufang Danshen liquid group). All patients were based on the criteria of the Fourth National Conference on Cerebrovascular Disease in 1995 and confirmed by cerebral MRI and CT as acute cerebral infarction. The treatment group given Kay injection, the control group to compound Danshen 16 mL low molecular weight dextran 500 mL. All subjects discontinued other anti-platelet aggregation anticoagulants and vasodilators before treatment. The two courses of treatment were 15 d, respectively, before treatment and 15 d after treatment for determination of hemorheology and nailfold microcirculation. Results After treatment, the hemorrheology in the treatment group showed that the whole blood high shear viscosity, whole blood low shear viscosity and fibrinogen decreased significantly, especially in the whole blood low shear viscosity and fibrinogen, which were significantly lower than those in the control group Rear. The control group after treatment than the indicators before the treatment a little better, but in addition to the viscosity of the whole blood except for the rest of the indicators by the statistical analysis, no significant difference. The changes of nailfold microcirculation before and after treatment in both groups were significantly improved after treatment of nailfold microcirculation, blood flow velocity, fluid state and so on, the total score decreased. The control group improved slightly after treatment. Conclusions Kay hours injection not only in the treatment of acute cerebral infarction has a significant effect, but also by improving blood flow, microcirculation and can prevent the occurrence and development of ischemic cerebrovascular disease, by prolonging the dosing time effect is better, it is worth Clinical further promotion and use.