本文研究大蒜对老年小鼠血浆IL 1β、IL 6水平变化的影响。小鼠经饮用大蒜液后 2周 ,继用 5 μgLPS/鼠腹腔注射 4h后 ,取血用ELISA测血浆中细胞因子水平。老年小鼠血浆IL 1β基础水平明显高于青年小鼠 (P <0 0 5 ) ,经LPS刺激后 ,老年小鼠血浆IL 1β、IL 6水平无明显增高 ,而饮用大蒜液后 ,老年小鼠的IL 1β、IL 6血浆基础水平有所降低 ,但在LPS刺激下 ,血浆IL 1β、IL 6较基础水平明显上升 (P <0 0 5 ) ,提示大蒜能明显改善老年小鼠的细胞因子紊乱状况。 This study was to investigate the effects of garlic on the plasma levels of IL-1β and IL-6 in aged mice. After 2 weeks of drinking garlic solution, mice were injected with 5 μg LPS / ip for 4 h, and blood samples were collected for determination of cytokine levels by ELISA. The basal level of IL-1β in plasma of aged mice was significantly higher than that of young mice (P <0.05). After LPS stimulation, there was no significant increase in plasma IL-1β and IL-6 levels in aged mice. After drinking garlic solution, (P <0.05), suggesting that garlic can significantly improve the cytokines in aged mice. However, the levels of IL-1β and IL-6 in plasma are lower than those in the control group situation.