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目的:探讨雷公藤多苷联合甲氨蝶呤在类风湿关节炎患者中的临床治疗效果及药代动力学。方法:选取我院诊治的80例患者资料进行分析,采用随机对照方法将患者分为两组,对照组采用甲氨蝶呤治疗,实验组在对照组基础上联合雷公藤多苷治疗,比较两组疗效及药代动力学。结果:实验组治疗后晨僵时间、关节疼痛数、关节压痛数、疼痛评分,显著低于对照组(P<0.05);实验组治疗后ESR、CRP、RF以及TNF~α指标,显著低于对照组(P<0.05)。结论:类风湿关节炎患者在甲氨蝶呤治疗基础上联合雷公藤多苷治疗效果理想,值得推广应用。
Objective: To investigate the clinical efficacy and pharmacokinetics of tripterygium glycosides combined with methotrexate in patients with rheumatoid arthritis. Methods: The data of 80 patients treated in our hospital were analyzed. The patients were divided into two groups by randomized controlled trial. Methotrexate was used as the control group. The experimental group was treated with tripterygium glycosides on the basis of the control group. Group efficacy and pharmacokinetics. Results: The scores of morning stiffness, joint pain, joint tenderness and pain score in experimental group were significantly lower than those in control group (P <0.05). After treatment, the indexes of ESR, CRP, RF and TNF-α in experimental group were significantly lower than those in control group Control group (P <0.05). Conclusion: Patients with rheumatoid arthritis combined with methotrexate on the basis of the treatment of tripterygium glycosides ideal effect, it is worth promoting the application.