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目的观察不同血流量血液灌流联合血液透析治疗尿毒症患者的临床效果。方法选择医院进行透析治疗的尿毒症患者60例,随机分为对照组和观察组,每组30例。2组患者采取不同血流量血液灌流联合血液透析治疗,对照组的血流量设定为200 ml/min,观察组的血流量设定为250 ml/min,观察2组患者治疗后的生化指标变化情况,尿素清除指数(Kt/V),甲状旁腺激素(PTH)清除率,瘙痒、睡眠干扰和总体评分以及凝血发生情况。结果在经过不同血流量血液灌流联合血液透析治疗后,观察组患者的生化指标变化情况、Kt/V值及PTH清除率等方面与对照组比较,差异无统计学意义(P>0.05)。但2组凝血指标及瘙痒、睡眠干扰和总体评分比较,观察组优于对照组,差异均有统计学意义(P<0.01)。结论采用血液灌流联合血液透析治疗尿毒症,选择250 ml/min血流量血液灌流优于200 ml/min血流量,可降低透析器凝血的发生率。
Objective To observe the clinical effects of hemoperfusion combined with hemodialysis in patients with uremia. Methods Sixty patients with uremia who underwent dialysis in our hospital were randomly divided into control group and observation group, 30 cases in each group. Two groups of patients with different blood flow hemodialysis combined with hemodialysis treatment, the control group, blood flow was set to 200 ml / min, the observation group, the blood flow was set to 250 ml / min, observed two groups of patients after treatment biochemical changes (Kt / V), parathyroid hormone (PTH) clearance, pruritus, sleep disturbance and overall score, as well as coagulation status. Results There was no significant difference in biochemical indexes, Kt / V and PTH clearance between the observation group and the control group after hemoperfusion and hemodialysis with different blood flow rates (P> 0.05). However, the coagulation index, pruritus, sleep disturbance and total score in the two groups were significantly higher than those in the control group (P <0.01). Conclusion Combined hemodialysis and hemodialysis for the treatment of uremia, blood flow of 250 ml / min is better than 200 ml / min of blood flow, which can reduce the incidence of hemodialysis.