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通过对北京市2004~2016年流行性腮腺炎的流行特征、病毒监测及SH基因序列的分析,与我国其他省份及全球参考病毒株序列进行同源性比较,阐述北京市腮腺炎病毒基因型分布和变异情况,报告新发现的G基因型病毒与我国其他地区病毒的相似性。研究发现从2007年随有免疫史病例增多病毒分离率明显下降,2010~2016年下降到10%以下。2016年分离到3株腮腺炎病毒,2株得到基因分型结果其中一株为F基因型,另一株G基因型。G基因型病毒与2011年陕西省流行的G基因型病毒最为接近。2004年至今,F基因型病毒一直为北京本地流行株。北京将腮腺炎纳入免疫规划后,随着本地优势流行病毒株的减少,发现了其他基因型病毒,因此应加强病毒监测,尽早发现并阻断新的病毒传播链。
Based on the epidemiological characteristics, virus surveillance and SH gene sequence analysis of mumps from 2004 to 2016 in Beijing, homology comparison with other provinces in China and global reference strains was carried out, and the mumps virus genotype distribution in Beijing And mutation, the report of the newly discovered G genotype and other parts of our country virus similarity. The study found that from 2007 with an increase in cases of immune history virus isolation rate decreased significantly from 2010 to 2016 dropped to below 10%. Three mumps viruses were isolated in 2016 and two were genotyped. One of them was F genotype and the other genotype was G genotype. The G genotype was the closest to the G genotype in Shaanxi province in 2011. Since 2004, F genotype virus has been a local epidemic in Beijing. With mumps included in the immunization program in Beijing, other genotype viruses have been found as the number of endemic pandemic strains declines. Virulence monitoring should therefore be strengthened to detect and block new viral transmission chains as soon as possible.