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目的 观察马兜铃属中药所致急性肾损伤时肾功能变化及组织形态学特点。方法 用马兜铃属中药水煎剂 [60g/ (kg.·d) ]按时间不同分 3组 (3、7、1 5d)给大白鼠灌胃 ,建立急性肾损伤动物模型 ,并与正常组和生理盐水组肾功能对照 ,检测有关肾功能指标 ,进行组织学观察。结果 马兜铃属大白鼠肾功能改变为 :氮质血症、低渗尿、蛋白尿、糖尿、血尿。组织形态学改变主要表现为急性肾小管坏死 ,肾小球出血、肾间质出血以及纤维化。结论 马兜铃属中药水煎剂可导致大鼠急性肾功能损伤。并发现其电解质紊乱的规律 ,提示临床注意。另一方面发现肾小球和肾皮质出血的病理变化等 ,对其机理进行了探讨 ,为进一步研究提供了依据
Objective To observe the changes of renal function and histomorphological features in acute kidney injury caused by Aristolochia. Methods Aristolochic medicine decoction [60g/ (kg.·d)] was used to administer the rats in 3 groups (3,7,15d) according to the time. Animal models of acute kidney injury were established and normal The renal functions of the group and the saline group were compared, and the relevant renal function parameters were measured and histological observation was performed. Results The renal function of Aristolochia was changed to azotemia, hypoosmotic, proteinuria, glucosuria, and hematuria. The main histological changes were acute tubular necrosis, glomerular hemorrhage, interstitial hemorrhage and fibrosis. Conclusions Aristolochi is a traditional Chinese medicine decoction that can cause acute renal injury in rats. And found that the law of electrolyte imbalance, prompted clinical attention. On the other hand, pathological changes such as glomerular and renal cortical hemorrhage were found, and the mechanism was discussed to provide a basis for further research.