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Raf激酶抑制蛋白是一种高度保守的表达蛋白,它作为促分裂原活化蛋白激酶信号级联反应的内源性调控者,在生物体的生长和分化中扮演着重要的作用。Raf激酶抑制蛋白位于促分裂原活化蛋白激酶级联反应的交叉口,能调控多条信号传导通路,主要通过调节Raf-1的活性来介导其调控机制。因此,Raf激酶抑制蛋白可能是促分裂原活化蛋白激酶级联通路中一个新的关键调控位点。
Raf kinase inhibitor is a highly conserved expression protein that plays an important role in the growth and differentiation of organisms as an endogenous regulator of the mitogen-activated protein kinase signaling cascade. The Raf kinase inhibitor, located at the intersection of the mitogen-activated protein kinase cascade, regulates multiple signaling pathways and regulates its regulatory mechanism mainly by modulating Raf-1 activity. Therefore, Raf kinase inhibitory protein may be a new key regulatory site in the mitogen-activated protein kinase cascade pathway.