端粒是位于真核细胞染色体末端的特殊蛋白结构,对维持线性染色体的稳定性至关重要,如何抑制端粒功能成为改进肿瘤治疗的新亮点。基于抑制端粒酶活性的抗肿瘤治疗存在不足,以端粒维持机制和端粒结构为靶点的抗肿瘤新策略已越来越受到重视,是富有前景的研究方向。 Telomere is a special protein structure located at the end of the chromosome of eukaryotic cells, which is crucial for maintaining the stability of linear chromosomes. How to inhibit telomere function has become a new bright spot in the improvement of tumor therapy. Anti-tumor therapy based on the inhibition of telomerase activity is insufficient, and new anti-tumor strategies targeting the telomere maintenance mechanism and telomere structure have drawn more and more attention and are promising research directions.