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开展本研究项目是为了验证这一假设,即在慢性肝炎的炎症过程中,包括病毒的复制,宿主的免疫反应和肝细胞的破坏是受一种肝内的细胞因子网络所调节。通过用逆转录聚合酶链反应的方法,调查二十例慢性丙型肝炎和九例慢性乙型肝炎的肝组织中,细胞因子IL1-β、IL_2、IL_4、IL_5、IL_6、TNF-α、IFN-r。淋巴细胞标记的CD_4和CD_8、HLAI类分子,B_2-MG的mRNA的表达。
The project was conducted to test the hypothesis that replication of the virus, including the replication of the virus, the immune response of the host, and the destruction of hepatocytes are regulated by a network of intrahepatic cytokines in the inflammatory process of chronic hepatitis. The levels of IL-1, IL-2, IL-4, IL-5, IL-6, TNF-α, IFN-γ in 20 chronic hepatitis C and nine chronic hepatitis B patients were investigated by reverse transcription polymerase chain reaction -r. Lymphocyte markers CD_4 and CD_8, HLAI class molecules, B_2-MG mRNA expression.