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目的 :观察克拉霉素、法莫替丁、阿莫西林三联疗法根治儿童幽门螺杆菌 (Hp)感染的疗效。方法 :将 62例确诊为Hp感染阳性患儿随机分为两组。治疗组用克拉霉素 7.5mg·kg 1 ,bid ,阿莫西林 2 0mg·kg 1 ,tid ,法莫替丁 0 .5mg·kg 1 ,bid ;对照组用甲硝唑 7.5mg·kg 1 ,tid,阿莫西林及法莫替丁的用法同治疗组。疗程均为 1周。结果 :治疗组Hp根除率 90 .3 % ,对照组 67.7% ,治疗组明显优于对照组 (P <0 .0 5)。两组患儿症状改善差异无显著性 (P >0 .0 5) ,不良反应均少见。结论 :克拉霉素、法莫替丁、阿莫西林三联 1周疗法疗效好 ,患儿依从性好
Objective: To observe the efficacy of triple therapy of clarithromycin, famotidine and amoxicillin in the treatment of children with Helicobacter pylori (Hp) infection. Methods: Sixty-two children diagnosed as Hp infection were randomly divided into two groups. The treatment group with clarithromycin 7.5mg · kg 1, bid, amoxicillin 20mg · kg 1, tid, famotidine 0.5mg · kg 1, bid; the control group with metronidazole 7.5mg · kg 1, tid, amoxicillin and famotidine use the same treatment group. The course of treatment is 1 week. Results: The eradication rate of Hp in the treatment group was 90.3% and that in the control group was 67.7%. The treatment group was significantly better than the control group (P <0.05). There was no significant difference in the improvement of symptoms between the two groups (P> 0.05), adverse reactions were rare. Conclusion: Clarithromycin, famotidine, amoxicillin triple therapy for 1 week has good curative effect and good compliance in children