Objective: To observe the clinical effect of Banxia Atractylodes macrocephala Tianma decoction in the treatment of hypertension. Methods: A total of 100 patients with hypertension were selected from our hospital (April 2016 to July 2019) and divided into 2 groups by random digital method. The control group was given routine symptomatic treatment of western medicine, and the observation group was given Banxia Atractylodes Gastrodia decoction on the basis of the control group. the levels of syndrome score and adiponectin (apn), cysc (cysc), uric acid (ua), c-reactive protein (crp), superoxide dismutase (sod), malondialdehyde (mda),8-hydroxydeoxyguanylic acid (8-ohdg) were recorded before and after treatment in group 2, and the total effective rate of clinical treatment was counted in group 2. Results: After treatment, the total effective rate (92.00％) in the observation group was higher than that in the control group (74.00％), and the difference was statistically significant (P<0.05). The APN、SOD level of the observation group was higher than that of the control group after treatment, and the CysC、UA、CRP、MDA、8-OHdG level and TCM symptom score were lower than those of the control group (P<0.05). Conclusion: Rhizoma Pinelliae and Rhizoma Gastrodiae decoction for treating hypertension can relieve oxidative stress injury, adjust the expression level of APN, CysC, CRP and UA, and improve the symptoms and improve the curative effect.