论文部分内容阅读
目的观察不同剂量盐酸吡格列酮(PIO)对糖尿病大鼠尿podocalyxin(PCX)排泄的动态影响。方法糖尿病大鼠分为DM组及PIO组(DR1、DR2、DR3组,分别给予PIO 10、20、30mg/(kg.d)。分别于0、4、8周末监测UAlb、Cr、尿PCX。结果(1)4周末,DR2和DR3组尿白蛋白肌酐比(UACR)较DM组显著降低(P<0.01),PIO各组尿PCX肌酐比(UPCR)与DM组相比差异无统计学意义。(2)8周末,DR2、DR3组UPCR较DM组显著降低(P<0.01),DR1组与DM组UPCR差异无统计学意义;PIO各组UACR均较DM组明显降低(P<0.01),DR2组和DR3组UACR较DR1组明显降低(P<0.05)。(3)UPCR与UACR呈正相关(r=0.86,P<0.01)。结论吡格列酮可抑制糖尿病大鼠PCX随尿排泄,并具有一定的剂量和时间依赖性。
Objective To observe the dynamic effects of different doses of pioglitazone hydrochloride on urinary podocalyxin (PCX) excretion in diabetic rats. Methods Diabetic rats were divided into DM group and PIO group (DR1, DR2, DR3 group, PIO 10, 20, 30mg / (kg.d) respectively), UAb, Cr and urinary PCX were monitored at 0, 4, Results (1) Urine albumin creatinine ratio (UACR) in DR2 and DR3 group was significantly lower than that in DM group (P <0.01) at 4 weeks. There was no significant difference in urine PCX creatinine ratio (UPCR) between PIO group and DM group . (2) At the end of the 8th week, the UPCR in DR2 and DR3 groups was significantly lower than that in DM group (P <0.01), while UPCR in DRI group and DM group was not significantly different. UACR in PIO groups was significantly lower than that in DM group (P <0.01) (P <0.05). (3) There was a positive correlation between UPCR and UACR (r = 0.86, P <0.01) .CONCLUSION Pioglitazone can inhibit the excretion of PCX in diabetic rats with Certain dose and time dependent.