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1967年,日本文献中初次描述了皮肤粘膜淋巴结综合征。如今,这种综合征是熟知的Kawasaki病。此病多发于儿童,50%的病例不到2岁,80%在四岁以内。文献中偶尔报导过此病也发生在成人。男女发病比率为1.5:1,此病常见于日本儿童及日裔夏威夷儿童。此病死亡率为1～2%。有心脏及末梢血管损害的病人至少占10%。虽然慢性病例增多,但其病因及长期影响仍不清楚。Kawasaki病的诊断标准包括发热(使用抗生素治疗无效)、皮肤损害、口唇舌裂缝变红、颈淋巴结肿大、结膜充血、手足水肿及出现皮疹。特殊表现可在心血管系统、胃肠道、中枢神经系统及其它系统中见到。
In 1967, mucosal lymph node syndrome was first described in Japanese literature. Today, this syndrome is a well-known Kawasaki disease. The disease occurs frequently in children, with 50% of cases being less than 2 years old and 80% being within 4 years of age. Occasionally reported in the literature, the disease also occurs in adults. Male to female incidence rate of 1.5: 1, the disease is common in Japanese children and Japanese-Hawaiian children. The disease mortality rate of 1 to 2%. At least 10% of patients have heart and peripheral vascular lesions. Although chronic cases increase, its etiology and long-term effects remain unclear. Diagnostic criteria for Kawasaki disease include fever (ineffective with antibiotics), skin damage, red lip crack, cervical lymph nodes, conjunctival congestion, hand-foot edema and rash. Special manifestations can be seen in the cardiovascular, gastrointestinal, central nervous system and other systems.