目的评价超声内镜(EUS)对原发性胃淋巴瘤(PGL)化疗的疗效评估及随访价值。方法 28例PGL行抗幽门螺杆菌(HP)联合化疗的患者,于化疗前、化疗第二疗程结束、化疗周期结束行超声内镜(EUS)检査,观察各阶段EUS下胃淋巴瘤声像学变化,对声像特征进行分析;并于化疗周期结束后3个月复査EUS,评估EUS对PGL治疗后的随访价值。结果化疗第2周期结束EUS提示浅表扩散型完全缓解2例、部分缓解3例、未缓解2例;早期弥漫浸润型完全缓解1例、部分缓解8例、未缓解4例;肿块型完全缓解1例、部分缓解2例、未缓解1例;混合型部分缓解4例;化疗周期结束EUS提示浅表扩散型完全缓解3例、部分缓解4例;早期弥漫浸润型完全缓解5例、部分缓解5例、未缓解3例;肿块型完全缓解2例、部分缓解1例、未缓解1例;混合型完全缓解2例、部分缓解2例;化疗周期结束后3个月复査EUS下取材活检,提示6例复发,并经病理证实。结论超声内镜可准确评估原发性胃淋巴瘤化疗疗效及监测复发。 Objective To evaluate the efficacy of endoscopic ultrasonography (EUS) in the treatment of primary gastric lymphoma (PGL) and its follow-up value. Methods Twenty-eight patients with PGL combined with Helicobacter pylori (HP) and chemotherapy were enrolled in this study. Before chemotherapy, the second course of chemotherapy was completed and the end of chemotherapy cycle was performed by endoscopic ultrasonography (EUS) To analyze the changes of audiovisual characteristics, and to review the EUS at 3 months after the end of the chemotherapy cycle to evaluate the follow-up value of EUS after PGL treatment. Results EUS at the end of the second cycle of chemotherapy showed superficial diffuse type complete remission in 2 cases, partial remission in 3 cases and no remission in 2 cases. Early diffuse infiltration type complete remission in 1 case, partial remission in 8 cases and no remission in 4 cases. 1 case, partial remission in 2 cases and no remission in 1 case; mixed partial remission in 4 cases; EUS prompt superficial diffuse type complete remission in 3 cases and partial remission in 4 cases at the end of chemotherapy cycle; early diffuse infiltration complete remission in 5 cases and partial remission 5 cases, 3 cases without remission; 2 cases with complete remission, 1 case with partial remission, 1 case without remission; 2 cases with mixed complete remission and 2 cases partially remission; , Prompted six cases of recurrence, and confirmed by pathology. Conclusion Ultrasound endoscopy can accurately evaluate the efficacy of chemotherapy for primary gastric lymphoma and monitor the recurrence.