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目的对妊高征患者进行抗心磷脂抗体（ACA）和抗DNA抗体的检测，探讨PIH与自身抗体间的关系。方法：采用酶联免疫（EIJSA）方法对30例PIH患者进行ACA－IgG、ACA－IgM、ACA－IgA、抗ds-DNA、抗SS－DNA抗体测定。结果：PIH患者中ACA的阳性率为63．3％（19／30），正常妊娠妇女为6.67％（2／30），其差异有高度显著性（P＜0．01）；PIH患者ACA的免疫球蛋白类型中以IgG型ACA最为常见，IgM型或IgA型ACA阳性常伴随有IgG型ACA阳性；妊高征组抗ds－DNA阳性率明显高于对照组（P＜0．01）；两组抗SS-DNA阳性率比较无显著意义。结论：ACA阳性、尤其是ACA－IgG阳性与妊高征发病有密切关系。表明ACA可作为一项判断孕妇能否正常妊娠的前瞻性指标。
Objective To detect anticardiolipin antibodies (ACA) and anti-DNA antibodies in patients with PIH and to explore the relationship between PIH and autoantibodies. Methods: Serum ACA-IgG, ACA-IgM, ACA-IgA, anti-dsDNA and anti-SS-DNA were detected in 30 PIH patients by enzyme-linked immunosorbent assay. Results: The positive rate of ACA was 63.3% (19/30) in PIH patients and 6.67% (2/30) in normal pregnant women, the difference was highly significant (P <0.01). The positive rate of ACA The most common type of immunoglobulin is IgG with ACA. The positive IgM or IgA ACA is often accompanied by ACA positive IgG. The positive rate of anti-dsDNA in PIH is higher than that of control (P <0.01). The positive rate of anti-SS-DNA in both groups was not significant. Conclusion: Positive ACA, especially ACA-IgG, is closely related to the pathogenesis of PIH. ACA can be used as a judge of pregnant women can be normal pregnancy forward-looking indicators.