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探讨内皮素(ET)、一氧化氮/一氧化氮酶( NO/NOS)在糖尿病与血管病变患者中的变化。ET采用放射免疫分析法,NO/NOS采用酶法。结果是:(1)糖尿病组ET水平(68.80±37.35)pg/mL)较对照组(41.70±21.50pg/mL)显著升高(P<0.001);NOS水平(2.75±1.49U/mL)明显高于对照组(1.12±0.56U/mL),P<0.01;NO水平(49.32± 16.32μmol/L)明显低于对照组(54.60 ±15.60μmol/L),P<0.05。(2)糖尿病合并血管病变组ET水(80.1140.25pg/mL)显著高于无并发症组(62.73±24.29pg/mL),P<0.001;NOS水平(4.02 ± 0.59U/mL)明显高于无并发症组(2.51±1.19U/mL),P<0.001;NO水平(42.25 ± 10.10/μmol/L)明显低于无并发症组(52.16±14.59mol/L,P<0.05;NO/NOS(11.99±7.05)明显低于无并发症组(26.9±13.15),P<0.001提示 ET、NO/NOS与糖尿病的发生和发展有关,联合检测不仅可作为糖尿病及其血管并发症的重要依据,还将有助于糖尿病合并血管病变的预防和治疗。
To investigate the changes of endothelin (ET), nitric oxide / nitric oxide enzyme (NO / NOS) in patients with diabetes mellitus and vascular diseases. ET using radioimmunoassay, NO / NOS enzymatic. The results were as follows: (1) The level of ET in diabetic group (68.80 ± 37.35 pg / mL) was significantly higher than that in control group (41.70 ± 21.50 pg / mL) (1.12 ± 0.56U / mL), P <0.01; NO level (49.32 ± 16.32μmol / L) was significantly lower than that of the control group (54.60 ± 15.60μmol / L), P <0.05. (2) The level of ET (80.1140.25pg / mL) in diabetic patients with vascular disease was significantly higher than that without complications (62.73 ± 24.29pg / mL), P <0.001; the level of NOS was 4.02 ± 0.59U / mL No complications (2.51 ± 1.19U / mL), P <0.001; NO levels (42.25 ± 10.10 / μmol / L) were significantly lower than those without complications (52.16 ± 14.59mol / L, P < (11.99 ± 7.05) was significantly lower than that of non-complication group (26.9 ± 13.15), P <0.001. ET and NO / NOS were associated with the occurrence and development of diabetes mellitus. Combined detection could not only serve as an important basis for diabetes mellitus and its vascular complications, Will also help prevent and treat diabetes with vascular disease.