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纤维结合蛋白(fibronectin,FN)是一种高分子糖蛋白,存在于血浆、细胞表面和细胞间基质中,具有诱导细胞分化、连接细胞和间质、参与血液凝固和机体防御,以及作为细胞活动和分裂的支撑点等重要功能,并与细胞的癌变有关。FN 的亚单位含有A 肽链、B 肽链和5个寡糖链。肽链可区分为7个功能性片段。初步查明了一些片段的氨基酸序列。最近开始了对FN 的基因分析。正常人血浆FN含量平均为330μg/ml。
Fibronectin (FN) is a kind of macromolecule glycoprotein which exists in plasma, cell surface and intercellular matrix, induces cell differentiation, connects cells and interstitium, participates in blood coagulation and body defense, and as a cell activity And split support points and other important functions, and with the cancer cells. Subunits of FN contain A peptide chain, B peptide chain and 5 oligosaccharide chains. The peptide chain can be divided into seven functional fragments. Preliminary identification of the amino acid sequence of some fragments. Recently the gene analysis of FN has started. Normal plasma FN content of an average of 330μg / ml.