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目的观察沙培林口服对胃癌术后患者的疗效。方法晚期胃癌术后患者58例,随机分为3组:A组口服沙培林,B组肌肉注射沙培林,C组口服安慰剂。分别观察和计算患者细胞免疫水平及生存率。结果沙培林口服组和肌肉注射组T细胞亚群CD3+、CD4+、CD4+/CD8+和NK水平均高于安慰剂组,而口服组和注射组之间差异无显著性。口服沙培林可能会延长患者生存期,口服沙培林无发热等不良反应。结论沙培林口服可提高胃癌术后患者的免疫力,并可能延长患者生存期,沙培林口服方便,副反应小,值得临床扩大试验。
Objective To observe the effect of oral administration of sapirin on postoperative patients with gastric cancer. Methods Fifty-eight postoperative patients with advanced gastric cancer were randomly divided into three groups: group A received oral sarin, group B received intramuscular injection of sapirin, and group C received placebo. Observe and calculate the patient’s cellular immunity level and survival rate respectively. Results The levels of CD3 +, CD4 +, CD4 + / CD8 + and NK of T cell subsets in oral and intramuscular injection groups were significantly higher than those in placebo group, but there was no significant difference between oral group and intramuscular injection group. Oral salinomycin may prolong the survival of patients, oral administration of sand pearl fever and other adverse reactions. Conclusion Oral administration of sapirin can improve the immunity of postoperative patients with gastric cancer and may prolong the survival of patients. Oral administration of sapirin is convenient and the side reaction is small, which deserves clinical trial.