对消化性溃疡的治疗,一般用制酸剂和/或抗胆碱能药物,虽有一定疗效,但不易使溃疡愈合,且有不少副反应,故不够理想。近年来,出现了胃蛋白酶抑制剂、胃粘膜屏障增强剂及组织再生促进剂等,似乎能减轻一些症状,但都不是针对病因的,难以达到治愈目的。1974年 Grossman 提出壁细胞膜上有三种受体(乙酰胆碱受体、组织胺 H_2受体和胃泌素受体)之后,开始从受体水平进行研究,其中抗胆碱能药物由于上述理由已不受重视:组织胺 H_2受体阻断剂甲氰咪胍经过5年多的广泛应用,已证明其疗效较好,尤其对十二指肠球部溃疡的疗效在 The treatment of peptic ulcer, the general use of antacids and / or anticholinergic drugs, although a certain effect, but not easy to ulcer healing, and there are many side effects, it is not ideal. In recent years, there have been pepsin inhibitors, gastric mucosal barrier enhancers and tissue regeneration promoters, it seems to reduce some symptoms, but not for the cause, it is difficult to achieve the purpose of cure. After Grossman proposed that there are three receptors on the parietal cell membrane (acetylcholine receptor, histamine H 2 receptor and gastrin receptor) in 1974, the study began at the receptor level, where anticholinergic drugs have not been affected by the above reasons Emphasis: Histamine H 2 receptor blocker Cimetidine After more than 5 years of extensive application, has proved its efficacy is better, especially for the efficacy of duodenal ulcer in