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癫癎从其发病机制上看,主要是兴奋性和抑制性神经元活动发生不平衡所致,而离子通道是体内兴奋性调节的基础,其结构功能变化将导致兴奋性调节发生障碍诱发癫癎的产生。离子通道按特性可分为电压门控离子通道和配体门控离子通道,目前已有许多研究证明这两者与癫癎有密切关系。本文主要对离子通道及其相关癫癎的某些发病机制、研制新型抗癫癎药物的理论基础予以综述。
Epilepsy from the pathogenesis point of view, mainly due to excitability and inhibitory neuronal activity imbalance caused by the ion channel is the basis of excitatory regulation of the body, the structural changes in function will lead to excitability regulation disorders induced epilepsy The production. According to the characteristics of ion channels can be divided into voltage-gated ion channels and ligand-gated ion channels, there are many studies have shown that both are closely related with epilepsy. This article mainly reviews the pathogenesis of ion channels and their related epilepsy and the theoretical basis for the development of new antiepileptic drugs.