目的:探讨hCG注射日子宫内膜上段和中段2个测量点的厚度之差与体外受精-胚胎移植(IVF-ET)妊娠结局之间的相关关系。方法:对初次接受IVF-ET治疗的256例患者,在hCG注射日行阴道超声测量子宫内膜最大厚度、上段厚度(距宫底10 mm处)、中段厚度(距宫底20 mm处)、上中段内膜差(ETD,即上段厚度-中段厚度)。根据ETD将患者分为4组:A组(ETD<0 mm);B组(ETD 0~2.0 mm);C组(ETD 2.1~4.0 mm);D组(ETD>4.0 mm),然后以年龄35岁为界将患者分为2个亚组:≥35岁和<35岁,比较各组的临床妊娠率、胚胎着床率和继续妊娠率。结果:年龄<35岁患者总的临床妊娠率为59.16%,4组胚胎着床率分别是39.3%、38.3%、51.2%和27.5%,4组之间有统计学差异(P=0.038 6)。4组的临床妊娠率为59.1%、60.6%、67.7%和45.0%(P=0.525);继续妊娠率为52.3%、50.0%、54.1%和30.0%,C组高于其余各组,但无统计学差异(P=0.296)。年龄≥35岁患者临床妊娠率为43.8%,较<35岁者低,且不同ETD组间各种观察数据无统计学差异(P>0.05)。结论:年轻患者ETD在2.1~4.0 mm范围时可能预示更佳的妊娠结局。 Objective: To investigate the correlation between the difference of thickness at the two measuring points in the upper and middle endometrium on hCG injection and pregnancy outcome of IVF-ET (IVF-ET). Methods: 256 patients who were treated with IVF-ET for the first time were examined by vaginal ultrasonography on the day of hCG injection to measure the thickness of the endometrium, the thickness of the upper segment (10 mm away from the fundus), the thickness of the middle segment (20 mm away from the fundus) In the middle of the poor endometrial (ETD, the upper section of the thickness - the middle of the thickness). Patients were divided into 4 groups according to ETD: group A (ETD <0 mm); group B (ETD 0-2.0 mm); group C (ETD 2.1-4.0 mm); group D (ETD> 4.0 mm) The 35-year-old community divided the patients into 2 subgroups: ≥35 years and ≤35 years. The clinical pregnancy rate, embryo implantation rate and continuous pregnancy rate were compared between groups. Results: The total clinical pregnancy rate was 59.16% in patients younger than 35 years old, 39.3%, 38.3%, 51.2% and 27.5% in 4 groups, respectively. There were significant differences among the 4 groups (P = 0.038 6) . The clinical pregnancy rates in the four groups were 59.1%, 60.6%, 67.7% and 45.0%, respectively (P = 0.525). The rates of continued pregnancy were 52.3%, 50.0%, 54.1% and 30.0% Statistical difference (P = 0.296). The clinical pregnancy rate was 43.8% in patients over 35 years of age, which was lower than that of <35 years old. There was no significant difference between the various ETD groups (P> 0.05). CONCLUSIONS: Young patients with ETD in the 2.1-4.0 mm range may predict better pregnancy outcomes.