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新生儿同种异体免疫性血小板减少症(NAIT)是与新生儿 Rh-溶血病类似,只是血小板是同种异体免疫抗体的靶,这种病是婴儿的血小板携带从父亲遗传的但母亲所缺乏的一种特异性抗原,这种结合可以导致母亲致敏,产生 IgG 抗血小板抗体。通过胎盘,这些抗体附着到胎儿的血小板并导致血小板减少症。已有几种血小板特异性抗原,但最常见是 PLA-1。1964年 Pearson 等报告 AIT 在新生儿中约有1/5000发病,而且由于颅内出血(ICH)伴有高达14%的围产期死亡率,ICH 在已报告的初次受累婴儿中可多达47%,而且
Neonates Alloimmune thrombocytopenia (NAIT) is similar to neonatal Rh-hemolytic disease except that platelets are targets of alloantibody antibodies that are inherited by their father’s platelets but lacking mothers Of a specific antigen, this combination can lead to the mother sensitized, produce anti-IgG platelet antibodies. Through the placenta, these antibodies attach to the fetus’s platelets and cause thrombocytopenia. Several platelet-specific antigens have been identified, but the most common is PLA-1. Pearson et al. Reported in 1964 that AIT had about 1 in 5000 neonates and that due to intracranial hemorrhage (ICH) with up to 14% of perinatal The mortality rate, ICH, can reach as much as 47% of reported first-time infants, and