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Wilms tumor gene 1(WT1) manifests both tumour suppressor and oncogenic activities,and WT1 can either activate or repress numerous target genes resulting in disparate biological effects.There are many researchs of WT1 gene in growth,development and tumor,in recent years WT1 gene on hematopoietic neoplasias research attracted the attention of people and some of the research results have been used in clinical work.This paper reviews the expression regulation,target genes and clinical application value study of WT1.