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[目的]探讨TS、ERCC1和DNA-PKcs在大肠癌组织中的表达及其临床意义。[方法]将133例大肠癌标本与17例正常大肠组织标本构建成组织芯片,应用免疫组化SP法检测TS、ERCC1和DNA-PKcs在大肠癌芯片中的表达,并分析其与大肠癌临床病理特征的关系。[结果]TS在大肠癌组织中的表达显著高于正常大肠组织(P<0.05),而ERCC1、DNA-PKcs在大肠癌组织中的表达与正常大肠组织无明显差异(P>0.05)。TS、ERCC1和DNA-PKcs的表达均与淋巴结转移和Dukes分期有关(P<0.05)。ERCC1和DNA-PKcs、TS和ERCC1表达间均呈明显正相关(P<0.01)。[结论]检测TS、ERCC1和DNA-PKcs在大肠癌中的表达对预测大肠癌的发生、发展有一定意义。
[Objective] To investigate the expression of TS, ERCC1 and DNA-PKcs in colorectal carcinoma and its clinical significance. [Method] 133 colorectal cancer specimens and 17 normal colorectal tissues were constructed into tissue microarrays. The expression of TS, ERCC1 and DNA-PKcs in colorectal cancer was detected by immunohistochemical SP method. Pathological characteristics of the relationship. [Results] The expression of TS in colorectal carcinoma was significantly higher than that in normal colorectal tissues (P <0.05). However, the expressions of ERCC1 and DNA-PKcs in colorectal carcinoma tissues were not significantly different from those in normal colorectal tissues (P> 0.05). The expression of TS, ERCC1 and DNA-PKcs were correlated with lymph node metastasis and Dukes stage (P <0.05). ERCC1 and DNA-PKcs, TS and ERCC1 expression were positively correlated (P <0.01). [Conclusion] Detecting the expression of TS, ERCC1 and DNA-PKcs in colorectal cancer has certain significance in predicting the occurrence and development of colorectal cancer.