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目的:探讨西地那非与硫酸镁联合治疗新生儿持续性肺动脉高压的临床效果及价值。方法:以我院于2015年1月—2016年1月间收治的50例持续性肺动脉高压患儿为研究对象,按照时间顺序将其分为两组,采用西地那非与硫酸镁联合治疗的观察组(25例)和采用单纯硫酸镁治疗的对照组(25例),对比两种治疗方法的效果。结果:观察组患儿的治疗总有效率为96%,明显高于对照组的72%,两组差异有统计学意义(P<0.05)。结论:对持续性动脉高压患儿实施西地那非与硫酸镁联合治疗,效果显著,值得推广和应用。
Objective: To investigate the clinical effect and value of sildenafil and magnesium sulfate in the treatment of persistent pulmonary hypertension in newborns. Methods: Fifty patients with persistent pulmonary hypertension treated in our hospital from January 2015 to January 2016 were divided into two groups according to their chronological order. The patients were treated with sildenafil and magnesium sulfate (25 cases) and the control group (25 cases) treated with magnesium sulfate alone, and compared the effects of the two treatment methods. Results: The total effective rate in treatment group was 96%, which was significantly higher than that in control group (72%). The difference between the two groups was statistically significant (P <0.05). Conclusion: The combination therapy of sildenafil and magnesium sulfate in children with persistent arterial hypertension has remarkable effect and is worth popularizing and applying.