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目的分析结核病患者发生耐药性危险因素,总结预防耐药的对策。方法选择2012年3月-2014年期间温州市中心医院收治的180例结核病患者,通过耐药性实验将患者分为耐药组与非耐药组,按照自制的《结核病耐药影响因素调查表》对所有患者进行调查,分析结核病患者发生耐药性危险因素。结果经过耐药性实验分析,180例结核病患者出现80例耐药患者,比例占44.4%,非耐药患者100例,比例55.6%;在耐药组与非耐药组中不同的居住地、文化水平、治疗史、治疗是否中断、吸烟史、治疗依从性、DOST执行状况以及是否患有糖尿病分布差异均有统计学意义(P<0.05)。性别、年龄、年均收入以及饮酒史差异无统计学意义(P>0.05)。结论治疗中断、DOST执行状况差、复治、患有糖尿病、治疗依从性差、有吸烟史、居住地农村、文化水平低均是影响结核病患者发生耐药性的危险因素,采取具有针对性的措施,能够降低结核病耐药性患者的发生率。
Objective To analyze the risk factors of drug resistance in tuberculosis patients and to summarize the strategies of preventing drug resistance. Methods 180 patients with tuberculosis admitted to Wenzhou Central Hospital between March 2012 and 2014 were divided into drug-resistant group and non-drug-resistant group through drug resistance test. According to the self-made Questionnaire on Influential Factors of Tuberculosis Drug Resistance All patients were surveyed to analyze the risk factors for drug-resistance in TB patients. Results After analysis of drug resistance, 80 cases of drug-resistant TB patients were found in 180 cases, accounting for 44.4%, 100 cases of non-drug-resistant patients, accounting for 55.6% of the total. Of the resistant and non-resistant groups, The level of education, treatment history, discontinuation of treatment, smoking history, treatment compliance, the status of DOST and whether there was a significant difference in the distribution of diabetes were statistically significant (P <0.05). There was no significant difference in sex, age, average annual income and drinking history (P> 0.05). Conclusions Treatment discontinuation, poor performance of DOST, retreatment, diabetes mellitus, poor treatment compliance, history of smoking, rural residence and low level of culture all are risk factors influencing drug resistance in TB patients. Targeted measures , Can reduce the incidence of tuberculosis drug resistance in patients.