正常细胞分裂和分化过程受生长因子调控；在肿瘤的生长及转移过程中，一些生长因子及肿瘤细胞表面生长因子受体亦起着决定性作用。目前已发现肿瘤细胞的凋亡、转化、浸润性生长及远处脏器转移与胰岛素样生长因子Ⅰ（ Ｉ Ｇ ＦⅠ） 及其受体（ Ｉ Ｇ ＦⅠ Ｒ） 有关。肿瘤细胞表面的 Ｉ Ｇ ＦⅠ Ｒ 表达的高低、周围微环境中的 Ｉ Ｇ ＦⅠ浓度大小，在一定程度上决定了该肿瘤细胞的致瘤性及转移特性。 The process of normal cell division and differentiation is regulated by growth factors. In the process of tumor growth and metastasis, some growth factors and tumor cell surface growth factor receptors also play a decisive role. It has been found that apoptosis, transformation, invasive growth, and distant organ metastasis of tumor cells are related to insulin-like growth factor I (IGF-I) and its receptor (IGF-IR). The level of IGF-IR expression on the surface of tumor cells and the concentration of IGF-I in the surrounding microenvironment determine the tumorigenicity and metastasis characteristics of the tumor cells to a certain extent.