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目的:探讨芳香化酶p450和凋亡抑制因子Survivin在子宫肌腺瘤组织中的表达情况。方法:选择我院收治的经手术切除、病理证实的子宫肌腺瘤标本60例作为观察组,同期选择正常增殖期宫内膜60例标本作为对照组,2组都进行芳香化酶p450和Survivin的免疫组化分析。结果:Survivin阳性染色主要定位于子宫内膜腺上皮细胞浆,阳性物质呈淡黄色或黄色颗粒状;芳香化酶P450主要分布于子宫内膜的细胞质,阳性细胞质呈棕黄色颗粒。观察组的芳香化酶p450和Survivin表达阳性率分别为56.7%和61.7%,而对照组的表达阳性率都为0.0%,对比差异都有统计学意义(P<0.05)。结论:芳香化酶p450和Survivin表达可以作为判断子宫肌腺瘤发生发展、预后的良好指标之一,对于早期预测子宫肌腺瘤有重要的临床意义。
Objective: To investigate the expression of aromatase p450 and apoptosis inhibitor Survivin in uterine adenoma tissue. Methods: Sixty cases of uterine adenoma confirmed by pathology and pathology were selected as the observation group. Sixty cases of endometrium in the normal proliferative phase were selected as the control group. Aromatase p450 and Survivin Immunohistochemical analysis. Results: Survivin positive staining mainly located in the endometrial glandular epithelial cells, the positive substance was light yellow or yellow granular; aromatase P450 mainly distributed in the cytoplasm of the endometrium, the positive cytoplasm was brown granules. The positive rates of p450 and Survivin expression in the observation group were 56.7% and 61.7%, respectively, while those in the control group were all 0.0%. The differences were statistically significant (P <0.05). CONCLUSION: The expression of aromatase p450 and Survivin can be used as a good indicator of the prognosis and prognosis of uterine adenoma. It has important clinical significance for the early prediction of uterine adenoma.