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目的:丹红注射液联合缬沙坦对早期糖尿病肾病(diabetic nephropathy,DN)患者血清胱抑素C(Cystatin C,Cys-C)与β2微球蛋白(β2-microglobulin,β2-MG)的影响。方法:选取96例早期DN患者,随机分为观察组(n=48)和对照组(n=48)。对照组给予缬沙坦,观察组给予丹红注射液联合缬沙坦,连续治疗2周。比较两组比较两组患者治疗前后空腹血糖(fasting blood glucose,FBG)、尿蛋白排泄率(urinary albumin excretion rate,UAER)、肌酐(creatinine,Cr)、血尿素氮(blood urea nitrogen,BUN)、血清Cys-C及β2-MG。结果:治疗后,观察组患者FBG、UAER、Cr、BUN、Cys-C及β2-MG分别为(6.6±0.6)mmol/L、(68.5±21.3)mg/24 h、(62.1±8.3)μmol/L、(5.8±1.7)mmol/L、(1.0±0.3)mg/L、(1.9±0.2)mg/L;对照组分别为(6.8±0.8)mmol/L、(124.0±32.2)mg/24 h、(62.5±7.4)μmol/L、(6.1±2.2)mmol/L、(1.7±0.3)mg/L、(2.8±0.3)mg/L;观察组Cys-C、β2-MG及UAER显著低于对照组,组间比较差异具有统计学意义(P<0.05);两组患者FBG、Cr及BUN比较无统计学差异(P>0.05)。结论:丹红注射液联合缬沙坦治疗早期DN患者,可显著改善肾小球滤过率,减少尿蛋白,从而达到肾脏保护作用。
Objective: To study the effects of Danhong injection combined with valsartan on serum levels of Cystatin C (Cys-C) and β2-microglobulin (β2-MG) in patients with early diabetic nephropathy (DN) . Methods: Ninety-six patients with early DN were selected and randomly divided into observation group (n = 48) and control group (n = 48). The control group was given valsartan, the observation group was given Danhong injection combined with valsartan, continuous treatment for 2 weeks. The levels of fasting blood glucose (FBG), urinary albumin excretion rate (UAER), creatinine (Cr), blood urea nitrogen (BUN) Serum Cys-C and β2-MG. Results: After treatment, FBG, UAER, Cr, BUN, Cys-C and β2-MG of the observation group were (6.6 ± 0.6) mmol / L, (68.5 ± 21.3) mg / 24 h and (62.1 ± 8.3) μmol (6.8 ± 0.8) mmol / L, (124.0 ± 32.2) mg / L, (1.0 ± 0.3) mg / L, 24 h, 62.5 ± 7.4 μmol / L, 6.1 ± 2.2 mmol / L, 1.7 ± 0.3 mg / L and 2.8 ± 0.3 mg / (P <0.05). There was no significant difference in FBG, Cr and BUN between the two groups (P> 0.05). Conclusion: Danhong injection combined with valsartan in early DN patients can significantly improve the glomerular filtration rate, reduce urinary protein, so as to achieve the role of renal protection.