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目的:观察孕早期HBsAg阳性孕妇流产胎盘组织(乙型肝炎病毒)HBV感染情况,分析可能的危险因素,为进一步探讨HBV宫内感染机制提供线索,并为预防措施的制订提供初步的理论依据。方法:采用巢式病例对照研究,对355例自愿流产孕妇中外周血HBsAg阳性者按统一的调查表进行调查,并对其流产胎盘进行免疫组化和HBVDNA原位杂交检测,运用SPSS10.0统计软件对资料和结果进行统计处理和分析。结果:孕妇HBsAg携带率为7%;早期发育的胎盘HBV感染率为32%;孕妇外周血HBVDNA的高浓度(OR=22.5,P=0.004)和HBeAg阳性(OR=12.5,P=0.008),是孕早期胎盘感染的主要危险因素。结论:HBV可感染早期发育的胎盘,感染率为32%;血HBVDNA的高浓度和HBeAg阳性的孕妇,其孕早期胎盘感染HBV的可能性较大。
Objective: To observe the HBV infection of abortion placenta (Hepatitis B virus) in HBsAg positive pregnant women during the first trimester of pregnancy and to analyze the possible risk factors so as to provide clues for further exploring the intrauterine infection mechanism of HBV and to provide a preliminary theoretical basis for the formulation of preventive measures. Methods: A nested case-control study was conducted to investigate the HBsAg positive in peripheral blood of 355 cases of spontaneous abortion among pregnant women according to a unified questionnaire. Immunohistochemistry and HBVDNA in situ hybridization were used to detect abortion placenta. SPSS10.0 statistics Software for statistical processing and analysis of data and results. Results: The HBsAg carrier rate was 7% in pregnant women and 32% in early placenta. The positive rates of HBVDNA in pregnant women were higher (OR = 22.5, P = 0.004) and HBeAg positive (OR = 12.5, P = 0.008) Pregnancy is the main risk of placental infection in early pregnancy. CONCLUSION: HBV can infect early placenta with a prevalence of 32%. High levels of HBVDNA and HBeAg positive pregnant women are more likely to have placental infection in early pregnancy.