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目的观察多潘立酮联合阿米替林治疗消化不良的临床效果。方法将127例消化不良患者按治疗方式的不同分为3组。A组41例患者给予多潘立酮治疗,B组41例患者给予阿米替林治疗,而C组45例患者则给予多潘立酮和阿米替林联合治疗。观察三种治疗方法下的临床总有效和不良反应率差异,比较3组患者的复发率和胃电图正常率情况。结果 C组患者的临床治疗总有效高达95.56%(43/45),明显高于A、B组的85.37%(35/41)、68.29%(28/41);并且C组患者的不良反应率为6.67%(3/45),明显低于A、B组的19.51%(8/41)、41.46%(17/41);另外,C组患者随访3个月的复发率为4.44%(2/45),胃电图正常率为73.33%(33/45),也显著优于A、B组,组间比较差异均具有统计学意义(P<0.05)。结论多潘立酮联合阿米替林应用于消化不良的治疗中较单纯药物治疗的临床疗效更优,且安全性好,值得在临床上推广使用。
Objective To observe the clinical effect of domperidone combined with amitriptyline in the treatment of dyspepsia. Methods 127 patients with dyspepsia were divided into three groups according to the different treatment methods. Forty-one patients in group A received domperidone, 41 in group B received amitriptyline, and 45 in group C received domperidone in combination with amitriptyline. To observe the difference between the total effective rate and the adverse reaction rate under the three treatment methods, and to compare the recurrence rate and normal rate of gastric electrogastrogram in the three groups. Results The total effective rate of clinical treatment in group C was 95.56% (43/45), significantly higher than 85.37% (35/41) and 68.29% (28/41) in group A and B, respectively. The adverse reaction rate in group C Was 6.67% (3/45), significantly lower than 19.51% (8/41) and 41.46% (17/41) in group A and group B. In addition, the recurrence rate in group C at 3 months was 4.44% (2 / 45). The normal rate of electrogastrogram was 73.33% (33/45), which was also significantly better than that of group A and B. The difference between the two groups was statistically significant (P <0.05). Conclusion Domperidone combined with amitriptyline in the treatment of dyspepsia than the simple clinical efficacy of drug treatment is better, and good safety, it is worth to promote the use of the clinic.