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[目的]观察血管内皮生长因子C(VEGF-C)及其受体3(VEGFR-3)在食管癌组织中的表达,探讨其意义。[方法]采用免疫组织化学法检测食管鳞癌和癌旁食管组织中的VEGF-C、VEGFR-3的表达。[结果]食管鳞癌组织中VEGF-C和VEGFR-3表达阳性率分别为70.3%(23/46),76%(23/46),癌旁组织中表达阳性率分别为20%,14%,两者比较差异有统计学意义,P均﹤0.05。VEGF-C和VEGFR-3的表达与食管癌的淋巴结转移、浸润深度有关,但与肿瘤组织分化程度无关。[结论]VEGF-C、VEGFR-3的表达与食管鳞癌的发展,淋巴结转移有相关性。
[Objective] To investigate the expression of vascular endothelial growth factor C (VEGF-C) and its receptor 3 (VEGFR-3) in esophageal cancer and to explore its significance. [Method] Immunohistochemistry was used to detect the expression of VEGF-C and VEGFR-3 in esophageal squamous cell carcinoma and para-cancerous esophageal tissues. [Results] The positive rates of VEGF-C and VEGFR-3 in esophageal squamous cell carcinoma were 70.3% (23/46) and 76% (23/46), respectively. The positive rates of VEGF-C and VEGFR- , The difference between the two was statistically significant, P <0.05. The expression of VEGF-C and VEGFR-3 was correlated with lymph node metastasis and depth of invasion in esophageal cancer, but not with the degree of tumor differentiation. [Conclusion] The expressions of VEGF-C and VEGFR-3 are correlated with the development of esophageal squamous cell carcinoma and lymph node metastasis.