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英国有两种卡介苗(BCG)制剂:皮内注射苗和经皮接种苗.经皮接种苗的浓度是皮内注射苗的10倍,用于新生儿接种,用改良的喷射枪射入2mm深度,而BCG的标准接种途径是皮内注射.这两种制剂的包装和标签相似,极易弄错.本文即为误将经皮接种BCG注入学龄儿童皮内的反应报告.32名学龄儿童(11～14岁)皮内注射了0.1ml BCG,其中19人注射经皮接种苗(含菌数为0.5亿～2.5亿CFU/ml),13人注射皮内注射苗(含菌数为800万～2600万CFU/ml).结果显示,接种后经皮接种苗组硬结进行性增大,2周时的平均直径为0.96cm;3周时为1.15cm;6周时为1.23cm;而15周时则缩小到0.9cm.皮内注射苗组2周时为0.83cm;3周时为0.83cm;6周时为0.77cm.接种后两组都出现发痒、溃疡和溢液等症状,不过6周时经皮接种苗组溢液发生率为9/15,而皮内注射苗组则为1/10.28周时经皮接种苗组症状消失,形成平均直径为1.2cm的瘢痕.
There are two BCG preparations in the UK: intradermal and transdermal seedlings, which are 10 times more potent than intradermal seedlings for neonatal inoculation with a modified injection gun 2mm depth, and BCG’s standard route of administration is intradermal injection.These two formulations are similar to the packaging and labeling, easy to make mistakes.This article is wrongly transplanted BCG injected intradermally into the skin of children reported reaction.32 school-age Children (11-14 years old) injected intradermally with 0.1 ml of BCG, of which 19 were inoculated by transdermal inoculation (containing 500 million to 250 million CFU / ml bacteria) and 13 injected with intradermal injection 8 million to 26 million CFU / ml) .The results showed that after inoculation seedlings transplanted seedlings increased agglutination, 2 weeks, the average diameter of 0.96cm; 3 weeks to 1.15cm; 6 weeks to 1.23 cm and decreased to 0.9 cm at 15 weeks, 0.83 cm at 2 weeks in the intradermal injection group, 0.83 cm at 3 weeks and 0.77 cm at 6 weeks. Itching, ulcers and spills occurred in both groups after inoculation Fluid and other symptoms, but at 6 weeks the incidence of transdermal inoculation seedlings group was 9/15, while the intradermal injection of seedlings group was 1 / 10.28 weeks when the symptoms of transdermal seedlings disappeared to form an average diameter of 1.2 cm scar.