抗生素类药物性质多不稳定,常受溶媒、温度、放置时间等因素的影响。因此,临床输注时,除考虑环境温度、输注时间外,亦应选择适宜的液体。本文浅述如下: 一、青霉素G 其在不同的溶媒中,分解速度各异。陈氏实验证明,25℃时,此药在5%、10%葡萄糖液中有效期仅2小时。原因有二。一是葡萄糖能催化青霉素的水解;二是上述二液体pH的值对青霉素G不宜(青霉素G的最适pH为6～6.5,5%,10%葡萄糖液pH为3.2～5.5)。可见,5%,10%葡萄糖不宜作该药的溶媒,盛夏时节(室温高达37℃)尤为不适。如需应用、室温应控制在20℃和25℃以下,并分别在4小时和2小时内输完。0.9%氯化钠和复方氯化钠溶液pH为4.7～7,青霉素在其中较为稳定,有效期在8小时以上,故此药物宜溶于 The nature of antibiotics is unstable and is often affected by factors such as the media, temperature, and placement time. Therefore, clinical infusion, in addition to taking into account the ambient temperature, infusion time, should also choose the appropriate liquid. This article briefly described as follows: First, penicillin G in different solvents, different decomposition rates. Chen’s experiments show that, at 25 ℃, the drug is valid for only 2 hours in 5%, 10% glucose solution. There are two reasons. First, glucose can catalyze the hydrolysis of penicillin; second is the above two liquid pH value of penicillin G is not appropriate (penicillin G optimum pH of 6 to 6.5, 5%, 10% glucose solution pH of 3.2 to 5.5). Visible, 5%, 10% glucose should not be used as the drug vehicle, summer season (room temperature up to 37 ℃) is particularly uncomfortable. For applications, room temperature should be controlled at 20 ℃ and 25 ℃ below, and were lost in 4 hours and 2 hours. 0.9% sodium chloride and compound sodium chloride solution pH of 4.7 to 7, of which penicillin is more stable, valid for more than 8 hours, so the drug should be soluble in