[目的]寻求特殊内镜技术联合定点深度活检对食管癌诊断的准确性。[方法]对普通内镜检查高度怀疑食管癌但首次病理未能证实的病例,采用i-Scan技术及超声内镜引导定点对增生明显的病灶行再次深度活检,取标本3~5块进一步病检。[结果]27例采用i-Scan技术、5例采用超声内镜引导下深度活检,病理均确诊为鳞状上皮癌。[结论]特殊内镜技术应用联合定点深度活检,能明显提高食管癌诊断的准确率。 [Objective] To seek the accuracy of special endoscopic technique combined with fixed-point depth biopsy for the diagnosis of esophageal cancer. [Methods] The cases of esophageal cancer who were highly suspected by ordinary endoscopy but failed to confirm for the first time were examined with i-Scan technique and endoscopic ultrasonography for further deep biopsy of lesions with 3 to 5 specimens Check [Results] 27 cases were diagnosed as squamous cell carcinoma by i-Scan technique and 5 cases by ultrasound endoscopy-guided deep biopsy. [Conclusion] Combined endoscopic biopsy with special endoscopic technique can significantly improve the diagnostic accuracy of esophageal cancer.