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近年来“间质性肾炎”一词用于特指一种临床病理状况,其特征为患者与多种药物接触后,发生轻重不等的肾功能衰竭。本文详细分析了25份连续活检之肾标本,其组织学表现为肾小管与间质病变和间质炎症均颇显著,且较肾小球的改变更为严重。绝大部分患者有急性肾功能衰竭。有肾小管炎的标本计10份,无肾小管炎的共15份。前者中9份的间质有嗜酸细胞[内4份有肾小球肾炎或肾小球硬化,但无动脉炎(B组);4份既无
In recent years, the term “interstitial nephritis” is used to refer specifically to a clinicopathological condition characterized by varying severity of renal failure after exposure to multiple drugs. In this paper, a detailed analysis of 25 consecutive biopsies of renal specimens, the histological manifestations of tubulointerstitial lesions and interstitial inflammation were significant, and glomerular changes more serious. Most patients have acute renal failure. There are 10 specimens of tubulitis, a total of 15 without tubulitis. Nine of the former had eosinophils in the mesenchyme [within 4 patients had glomerulonephritis or glomerulosclerosis, but no arteritis (group B); 4 neither