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目的观察参芎葡萄糖注射液对慢性阻塞性肺疾病(COPD)合并肺心病心力衰竭患者血N-端脑钠肽前体值(NT-pro BNP)的影响。方法 76例慢性阻塞性肺病疾病合并肺心病心力衰竭患者,随机分为对照组及治疗组,各38例。对照组给予常规基础治疗,治疗组在对照组基础上联合参芎葡萄糖注射液静脉滴注。检测两组患者治疗前后N-端脑钠肽前体值。结果治疗组总有效率(84.2%)高于对照组(71.1%),差异有统计学意义(P<0.05);治疗组较对照组血NT-pro BNP下降明显,差异有统计学意义(P<0.05)。结论参芎葡萄糖注射液可显著降低慢性阻塞性肺疾病合并肺心病心力衰竭患者的N-端脑钠肽前体水平,对改善心力衰竭疗效明显,值得临床推广。
Objective To observe the effect of Shenxiong and glucose injection on N-terminal proBNP (NT-pro BNP) in patients with chronic obstructive pulmonary disease (COPD) complicated with cor pulmonale and heart failure. Methods Sixty-six patients with chronic obstructive pulmonary disease complicated with pulmonary heart disease and heart failure were randomly divided into control group and treatment group, with 38 cases in each group. The control group was given routine basic treatment. The treatment group was given intravenous infusion of Shenxiong glucose injection on the basis of the control group. N-terminal pro-brain natriuretic peptide levels were measured before and after treatment in both groups. Results The total effective rate (84.2%) in the treatment group was significantly higher than that in the control group (71.1%) (P <0.05). The blood NT-pro BNP level in the treatment group was significantly lower than that in the control group (P <0.05). Conclusion Shenxiong glucose injection can significantly reduce the level of N-terminal pro-brain natriuretic peptide in patients with chronic obstructive pulmonary disease and heart failure complicated with cor pulmonale, and has obvious curative effect on improving heart failure and is worthy of clinical promotion.