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目的 探索氧自由基在肺癌、急性肺部感染中的作用机制。方法 检测 3 2名肺癌、3 4名急性肺部感染患者血中SOD、LPO的含量 ,并与正常人进行对比研究 ,且将肺癌吸烟者、肺癌的不同组织类型间SOD、LPO进行比较。结果 肺癌组SOD下降 ,P <0 0 5 ,LPO升高但差异无显著性P >0 0 5 ,肺癌吸烟者和非吸烟者、肺癌各组织类型间LPO、SOD含量差异无显著性P >0 0 5。急性肺部感染组SOD、LPO均明显升高P <0 0 1和P <0 0 5。结论 SOD、LPO在肺癌和急性肺部感染中的作用机制不同 ,在肺癌中SOD下降 ,LPO相对增高 ,对机体造成损害。LPO在肺癌的不同组织类型中作用是一样的。在急性肺感染组SOD、LPO均较对照组升高。体内氧化抗氧化系统在一个新的较高水平上达到平衡 ,有利于杀灭病原菌。对机体有保护作用
Objective To explore the mechanism of oxygen free radical in lung cancer and acute lung infection. Methods The levels of SOD and LPO in blood of 32 lung cancer patients and 34 acute lung infection patients were detected and compared with those of normal subjects. The SOD and LPO of lung cancer among different types of lung cancer patients were also compared. Results There was no significant difference in the levels of SOD and SOD between the lung cancer group and the lung cancer group (P <0.05), LPO increased but the difference was not significant (P> 0.05). There were no significant differences in the levels of LPO and SOD between lung cancer patients and non-smokers 0 5. SOD and LPO in acute lung infection group were significantly increased P <0 01 and P 0 05. Conclusions The mechanism of action of SOD and LPO in lung cancer and acute lung infection is different. In lung cancer, SOD is decreased and LPO is relatively increased, which causes damage to the body. The role of LPO in different types of lung cancer is the same. In acute lung infection group SOD, LPO were higher than the control group. In vivo antioxidant system at a new higher level of balance, help kill pathogens. Have a protective effect on the body