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目的 :研究VitB6在妊娠中期引产后抑制泌乳的作用及其临床应用。方法 :6 0例妊娠中期孕妇经羊膜腔内注入雷夫奴尔 10 0mg引产 ,其中 30例术后不服药作为对照组 ,30例在术后 2小时开始服VitB66 0mgtid× 5天。两组均于术前及术后 4天以RIA法测定血清中PRL、E2 及P的水平 ,对结果作相关分析。同时观察乳汁分泌情况。结果 :血清三项激素水平虽在术后均较前明显下降 ,但服药组PRL下降更为明显 (P <0 .0 0 1vs0 .0 5 ) ,挤压乳房有泌乳者服药组仅 2例 ,而对照组有 9例。结论 :妊娠中止后 2小时内开始服VitB6能极为有效地抑制乳汁分泌 (93 3% ) ,可代替己烯雌酚等传统药物。血清PRL水平的显著下降 (42 85 % ) ,提供了完善的实验室资料。
Objective: To investigate the role of VitB6 in inhibiting lactation after induction of labor in the second trimester of pregnancy and its clinical application. Methods: Sixty pregnant women of the second trimester were injected with 100mg Lefranuron by intra-amniotic cavity. Among them, 30 were given no medication as control group and 30 patients received VitB66 0mgtid for 5 days after operation. Serum levels of PRL, E2 and P were measured by RIA before operation and 4 days after operation in both groups, and the results were analyzed. At the same time observe the milk secretion. Results: Although the levels of serum three hormones decreased significantly after the operation, the decrease of PRL in the medication group was more obvious (P <0.01 01 vs0.05) The control group, 9 cases. CONCLUSIONS: VitB6, taken within 2 hours after termination of pregnancy, can very effectively inhibit milk secretion (93.3%) and can replace traditional drugs such as diethylstilbestrol. Serum PRL levels decreased significantly (42 85%), providing a sound laboratory data.