论文部分内容阅读
哺乳动物的心肺功能对动脉血氧水平变化极其敏感。当可利用的氧气减少时,缺氧诱导因子(hypoxia-inducible factors,HIF)(例如,HIF-1和HIF-2)介导相应的转录反应。研究者证明在成年Hif-2+/-小鼠中,由O2-调节的HIF-2亚单位的单倍型不足可导致颈动脉体对缺氧、呼吸不规则、呼吸暂停和高血压的敏感性增强,以及血浆去甲肾上腺素的水平升高。上述异常的自主调节反应与肾上腺髓质的氧化应激增强、线粒体电
Cardiopulmonary function in mammals is extremely sensitive to changes in arterial oxygen levels. Hypoxia-inducible factors (HIFs) (eg, HIF-1 and HIF-2) mediate the corresponding transcriptional responses when available oxygen is reduced. Investigators have demonstrated that haplotype deficiency of O2-regulated HIF-2 subunits in adult Hif-2 +/- mice can lead to carotid body sensitivity to hypoxia, irregular breathing, apnea, and hypertension Sexual enhancement, and plasma norepinephrine levels. The above-mentioned abnormal autoregulation and adrenal medullary oxidative stress increased mitochondrial electrical