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以高碘饲料喂养4组小白鼠,平均每只日摄碘量分别为:1组1μg,2组6μg,3组50.8μg,4组101μg.150天后发现甲状腺肿和甲状腺炎。动物每日摄碘量和甲状腺的重量、甲状腺滤泡直径呈正相关,和动物的体重、甲状腺滤泡上皮细胞的高度呈负相关。甲状腺的组织学改变属巨滤泡性胶样甲状腺肿。超微结构显示细胞功能处于静止减弱的形态。8只动物(占14%)甲状腺组织中有不同程度的灶性或弥漫性淋巴细胞浸润,和高碘人群中自身免疫性甲状腺疾病(AITD)的改变相似,为探讨高碘与甲状腺自身免疫病的关系,提供了有价值的实验资料。
Four groups of mice were fed with high iodine diet. The average daily intake of iodine was 1 μg in group 1, 6 μg in group 2, 50.8 μg in group 3, and 101 μg in group 4. After 150 days, goiter and thyroiditis were found. Animal daily intake of iodine and thyroid weight, thyroid follicular diameter was positively correlated with the body weight of animals, thyroid follicular epithelial cells height was negatively correlated. Histological changes in thyroid gland is a giant follicular gel-like goiter. The ultrastructure shows that the cell function is in a quiescent state. Eight animals (14%) had varying degrees of focal or diffuse lymphocytic infiltration in the thyroid tissue, similar to the changes of autoimmune thyroid disease (AITD) in high-iodine populations. To investigate the association between high iodine and thyroid autoimmune diseases The relationship provides valuable experimental data.