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目的 探讨纤维蛋白原 (FBG)在化学性急性呼吸窘迫综合征 (ARDS)发病机制中的可能作用。方法 经尾静脉注射油酸制备ARDS大鼠模型 ,采用凝血酶法测定ARDS大鼠肺循环、颈动脉和静脉血浆中FBG含量。结果 给大鼠静脉注射油酸后 0 5h ,肺循环血中FBG水平即呈增加趋势 ,6h显著高于对照组 [( 2 495 .0± 338.9)mg/Lvs ( 15 72 .0± 2 86.8)mg/L ,P <0 .0 1] ,12h达峰值 [( 34 46.7± 317.2 )mg/L] ,72h仍维持在较高水平 ;12h、2 4h大鼠颈动脉、静脉血中FBG亦显著高于对照组。结论 ARDS在鼠肺循环血中FBG水平持续升高 ,且与ARDS病程有密切关系 ,提示FBG可能在介导肺血管内微血栓的形成、引起肺循环功能障碍以及肺纤维化中具有关键作用 ;肺循环血中FBG水平的监测对指导ARDS的临床治疗及预后评价也可能有重要参考价值。
Objective To investigate the possible role of fibrinogen (FBG) in the pathogenesis of chemical acute respiratory distress syndrome (ARDS). Methods ARDS rat model was induced by tail vein injection of oleic acid. The content of FBG in pulmonary circulation, carotid and venous plasma of ARDS rats was determined by thrombin method. Results The level of FBG in the blood of the pulmonary circulation increased at 0 h after intravenous injection of oleic acid, and was significantly higher at 6 h than that of the control group [(2 495.0 ± 338.9) mg / L vs (15 72.0 ± 2 86.8) mg / L, P <0.01], peaked at 12h [(34 46.7 ± 317.2) mg / L], and remained high at 72h; FBG in carotid and venous blood was also significantly higher at 12h and 24h In the control group. CONCLUSIONS: The continuous increase of FBG level in rat pulmonary blood with ARDS is closely related to the course of ARDS, suggesting that FBG may play a key role in mediating the formation of pulmonary micro-thrombosis, causing pulmonary circulatory dysfunction and pulmonary fibrosis. The monitoring of FBG levels may also have important reference value in guiding the clinical treatment and prognosis evaluation of ARDS.