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大量研究表明雌激素具有神经保护作用,但其机制尚不清楚。近年来研究提示,雌激素的神经保护作用与线粒体有着密切联系。线粒体是细胞内能量和活性氧自由基(ROS)的主要来源,对细胞内信号转导、细胞存活与死亡调节等具有十分重要的影响。在生理和病理条件下,雌激素可多方面调节线粒体功能,包括影响ATP与ROS的生成、稳定线粒体膜电位、维护细胞内钙稳态,以及调节线粒体基因和蛋白表达等。本文主要从线粒体角度综述了雌激素神经保护作用及其机制。
Numerous studies show that estrogen has neuroprotective effect, but the mechanism is still not clear. In recent years, research suggests that estrogen neuroprotection and mitochondria are closely linked. Mitochondria are the main sources of intracellular energy and reactive oxygen species (ROS), which play an important role in intracellular signal transduction, cell survival and death regulation. Under physiological and pathological conditions, estrogen can regulate mitochondrial function in many aspects, including affecting ATP and ROS production, stabilizing mitochondrial membrane potential, maintaining intracellular calcium homeostasis, and regulating mitochondrial gene and protein expression. In this paper, we reviewed the neuroprotective effect of estrogen and its mechanism from the perspective of mitochondria.