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目的：探讨认知行为治疗对产后抑郁症患者临床疗效及性激素水平的影响。方法将80例产后抑郁症患者分为A组与B组，将40名健康产妇设为对照组；A组与B组分别予以认知行为治疗及抗抑郁药物治疗，观察8周。于治疗前后采用汉密顿抑郁量表、副反应量表评定临床疗效及不良反应，同时检测3组被试雌二醇、孕酮及泌乳素水平。结果治疗8周末，A组痊愈率为63．2％，B组为65．8％，两组比较差异无显著性（ P＞0．05）。A组副反应量表的严重程度及痛苦感觉评分显著低于B组（P＜0．01）。入组时 A组B组雌二醇水平均显著低于对照组（P＜0．01），孕酮水平显著高于对照组（P＜0．01）；研究8周末A组与B组雌二醇水平显著升高（P＜0．01），孕酮水平显著降低（P＜0．01），3组间比较差异无显著性（P＞0．05），B组泌乳素水平显著低于A组及对照组（P＜0．01）。结论认知行为治疗对产后抑郁症患者有较好的疗效，无明显不良反应，有利于患者性激素水平恢复正常。“,”Objective To explore the influences of cognitive behavior therapy (CBT )on curative effect and sexual hormone levels of postpartum depression (PD) patient .Methods Eighty PD patients were assigned to group A and B and 40 healthy parturients to control group ;group A and B were treated with CBT and antidepressants for 8 weeks .Efficacies were assessed with the Hamilton Depression Scale (HAMD) before and after treatment and adverse reactions with the Treatment Emergent Symptom Scale (TESS) ,estradi‐ol ,progesterone and lactotropin levels detected for 3 groups at the same time .Results At the end of 8 week treatment cure rate was respectively 63 .2% in group A and 65 .8% in B ,which showed no significant group difference (P>0 .05) .Severity and pain score of the TESS were significantly lower in group A than in B (P<0 .01) .At enrolment estradiol levels of both group A and B were significantly lower (P<0 .01) and pro‐gesterone higher (P<0 .01) compared with control group ;at the end of 8 week treatment estradiol levels of both group A and B heightened significantly (P<0 .01) and progesterone lowered (P0 .05) ,and prolactin levels were significantly lower in group B than in A and control group (P<0 .01) .Conclusion CBT is effective in postpartum depression ,has no obvious adverse reactions ,and is beneficial to the recovery of sexual hormone levels .