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目的观察参麦注射液联合玉屏风颗粒治疗小儿支气管哮喘的临床疗效及安全性。方法将80例支气管哮喘患儿随机分成对照组40例和试验组40例。对照组予以静脉滴注参麦注射液40 m L,qd;试验组在对照组治疗的基础上,予以口服玉屏风颗粒每次5 g,tid。2组患者一个疗程均为14 d,共治疗2个疗程。比较2组患儿的临床疗效、治疗前和治疗后外周血中CD_4~+,CD_8~+,CD_4~+/CD_8~+水平、第1秒用力呼气容积(FEV1),以及药物不良反应的发生情况。结果治疗后,试验组和对照组的总有效率分别为97.50%(39/40例)和77.50%(31/40例),差异均有统计学意义(P<0.05)。治疗后,试验组和对照组的外周血中CD_4~+分别为(32.00±1.45)%,(35.05±0.97)%;CD_4~+/CD_8~+分别为(0.94±0.08),(1.06±0.09);CD_8~+分别为(34.13±1.96)%,(33.20±2.77)%;FEVl分别为(2.59±0.19),(2.22±0.11)L,差异均有统计学意义(P<0.01)。试验组的药物不良反应主要有面色潮红,对照组的药物不良反应主要有面色潮红、皮疹。试验组和对照组的药物不良反应发生率分别为2.50%和5.00%,差异无统计学意义(P>0.05)。结论参麦注射液联合玉屏风颗粒治疗小儿支气管哮喘的临床疗效显著,能显著提高患儿的免疫功能和肺功能,且不增加药物不良反应的发生率。
Objective To observe the clinical efficacy and safety of Shenmai injection combined with Yupingfeng granule in the treatment of pediatric bronchial asthma. Methods Eighty children with bronchial asthma were randomly divided into control group (40 cases) and experimental group (40 cases). The control group was given Shenmai injection intravenously 40 m L, qd; experimental group in the control group based on the treatment, oral Yupingfeng particles each 5 g, tid. Two groups of patients with a course of 14 days, a total of 2 courses of treatment. The clinical efficacy, the levels of CD_4 ~ +, CD_8 ~ +, CD_4 ~ + / CD_8 ~ + in the peripheral blood before and after treatment were compared between the two groups. The forced expiratory volume in 1 second (FEV1), and adverse drug reaction What happened? Results After treatment, the total effective rate was 97.50% (39/40) and 77.50% (31/40) respectively in the experimental group and the control group, with statistical significance (P <0.05). After treatment, the levels of CD_4 ~ + in the peripheral blood of the experimental group and the control group were (32.00 ± 1.45)% and (35.05 ± 0.97)%, respectively; and those of the CD_4 ~ + / CD_8 ~ + were (0.94 ± 0.08) and (1.06 ± 0.09 (34.13 ± 1.96)% and (33.20 ± 2.77)%, respectively. The FEV1 values were (2.59 ± 0.19) and (2.22 ± 0.11) L, respectively, with statistical significance (P <0.01). Adverse drug reactions in the experimental group mainly flushed, the control group of adverse drug reactions are mainly flushing, rash. The incidence of adverse drug reactions in the experimental group and the control group were 2.50% and 5.00%, respectively, with no significant difference (P> 0.05). Conclusion Shenmai injection combined with Yupingfeng granules in children with bronchial asthma clinical significant effect, can significantly improve children’s immune function and lung function, and does not increase the incidence of adverse drug reactions.