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目的研究替米沙坦和氨氯地平分别联合贝那普利对原发性高血压患者的治疗作用以及对左心室重构和血管弹性功能的改善作用。方法本院心内科2015年1月—2015年10月就诊的原发性高血压患者96例随机分为观察组A和观察组B。两组患者均口服贝那普利片10 mg/天,在此基础上,观察组A患者服用苯磺酸氨氯地平片5 mg/天,观察组B患者服用替米沙坦片40 mg/天,疗程均为6个月。测量治疗前后两组患者血压、左心室重构以及血管弹性相关指标,比较两组患者治疗期间的不良反应。结果 (1)治疗6个月时两组患者SBP和DBP均较治疗前显著降低(P<0.01),但是组间差异均无统计学意义(P>0.05);(2)两组患者控制血压的临床疗效差异无统计学意义(P>0.05);(3)治疗6个月时观察组B患者LVMI、LAESD、LVEDD和LVPWT较观察组A患者显著降低(P<0.01),而LVFS较观察组A患者显著升高(P<0.01);(4)治疗6个月时观察组B患者C1、C2较观察组A患者显著升高(P<0.01),而PWV较观察组A患者显著降低(P<0.01);(5)两组患者各不良反应的发生率及不良反应总发生率差异均无统计学意义(P>0.05)。结论替米沙坦联合贝那普利对原发性高血压患者的疗效和安全性与氨氯地平联合贝那普利相似,但是改善左心室构造和血管弹性作用优于氨氯地平联合贝那普利。
Objective To investigate the therapeutic effect of telmisartan and amlodipine combined with benazepril in patients with essential hypertension and the improvement of left ventricular remodeling and vascular elasticity. Methods 96 patients with essential hypertension admitted to our hospital from January 2015 to October 2015 were randomly divided into observation group A and observation group B. On the basis of observation, group A patients took amlodipine besylate tablets 5 mg / day, observation group B patients took telmisartan tablets 40 mg / Days, treatment are 6 months. Before and after treatment, blood pressure, left ventricular remodeling, and vascular elasticity were measured in two groups before and after treatment. Adverse reactions were compared between the two groups during treatment. Results (1) SBP and DBP in both groups were significantly lower than those before treatment at 6 months (P <0.01), but there was no significant difference between the two groups (P> 0.05); (2) (P> 0.05); (3) The LVMI, LAESD, LVEDD and LVPWT in observation group B were significantly lower than those in observation group A at 6 months (P <0.01) (4) At 6 months, C1 and C2 in observation group B were significantly higher than those in observation group A (P <0.01), but PWV was significantly lower in observation group A than in observation group (P <0.01) (P <0.01). (5) There was no significant difference in the incidence of adverse reactions and the total incidence of adverse reactions between the two groups (P> 0.05). Conclusion The efficacy and safety of telmisartan and benazapril in patients with essential hypertension are similar to that of amlodipine and benazepril. However, the improvement of left ventricular structure and blood vessel elasticity is superior to that of amlodipine and benazepril Puli.