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目的:观察奥卡西平治疗舌咽神经痛的临床疗效和安全性。方法:72例患者随机分为观察组和对照组各36例,观察组用奥卡西平治疗,对照组用卡马西平治疗。4周后比较两组疗效和不良反应发生情况。结果:观察组总有效率为75.0%,对照组治疗总有效率为61.1%。两组疗效比较,差异有统计学意义(P<0.05)。观察组疼痛缓解(VAS评分降低)优于对照组,两组比较差异有统计学意义(P<0.05)。观察组不良反应发生率低于对照组(P<0.05)。结论:奥卡西平治疗舌咽神经痛疗效确切,安全可靠,值得临床推广应用。
Objective: To observe the clinical efficacy and safety of oxcarbazepine in the treatment of glossopharyngeal neuralgia. Methods: Seventy-two patients were randomly divided into observation group and control group, with 36 cases in observation group and oxcarbazepine in observation group and carbamazepine in control group. After 4 weeks, the curative effects and adverse reactions of the two groups were compared. Results: The total effective rate was 75.0% in the observation group and 61.1% in the control group. The curative effect between the two groups, the difference was statistically significant (P <0.05). Pain relief (VAS score reduction) in the observation group was better than that in the control group, with significant difference between the two groups (P <0.05). The incidence of adverse reactions in the observation group was lower than that in the control group (P <0.05). Conclusion: Oxcarbazepine treatment of glossopharyngeal neuralgia curative effect is safe, reliable and worthy of clinical application.