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目的探讨乙型肝炎病毒(HBV)相关肝癌患者血清白介素28B(IL-28B)表达及意义研究,为诊断由乙型肝炎病毒导致的相关肝癌提供更加科学依据。方法选取慢性HBV感染的患者150例作为研究组,另选取同期50名健康志愿者作为对照组,检测血清IL-28B及甲胎蛋白(AFP)值等指标,采用SPSS17.0统计软件对数据进行统计分析,计量资料采用t检验;率的比较采用χ2检验。结果肝癌组与其他组比较,IL-28B及AFP均较高,其中,肝癌组IL-28B值可达(682.4±103.4)ρ/(pg·ml),明显高于对照组的(484.4±77.2)ρ/(pg·ml),差异有统计学意义(P<0.05);肝癌组AFP检测结果(98.5±66.5)ρ/(ng·ml),明显高于慢性乙型肝炎组的(14.4±8.3)ρ/(ng·ml),差异有统计学意义(P<0.05);IL-28B检测值与肝癌患者肿瘤数目有一定的关联,不同肿瘤数目组间比较,差异有统计学意义(t=11.256,P<0.05),而与肿瘤直径大小组间差异无统计学意义。结论结合AFP检测,可更加准确的诊断由乙型肝炎病毒导致的相关肝癌,值得临床检验继续深入探索。
Objective To investigate the expression and significance of serum interleukin 28 (IL-28B) in patients with hepatocellular carcinoma (HCC) related to hepatitis B virus (HBV) and to provide more scientific evidences for the diagnosis of HCC associated with hepatitis B virus. Methods A total of 150 patients with chronic HBV infection were selected as the study group. Another 50 healthy volunteers were enrolled in the study. Serum IL-28B and AFP levels were measured and SPSS17.0 statistical software was used to analyze the data Statistical analysis, measurement data using t test; rate comparison using χ2 test. Results The levels of IL-28B and AFP in HCC group were higher than those in other groups. IL-28B in HCC group was (682.4 ± 103.4) pg · ml, which was significantly higher than that in control group (484.4 ± 77.2) (P <0.05). The results of AFP in hepatocellular carcinoma (98.5 ± 66.5) ρ / (ng · ml) were significantly higher than those in chronic hepatitis B (14.4 ± 8.3) ρ / (ng · ml), the difference was statistically significant (P <0.05). The detection value of IL-28B was correlated with the number of tumor in HCC patients. The difference was statistically significant = 11.256, P <0.05), while there was no significant difference between tumor size and size. Conclusion Combined with AFP detection, more accurate diagnosis of liver cancer caused by Hepatitis B virus, it is worth further clinical exploration.